1 year of alendronate after 1 year of parathyroid hormone (1-84) treatment increased bone mineral density in osteoporosis.
نویسنده
چکیده
منابع مشابه
One year of alendronate after one year of parathyroid hormone (1-84) for osteoporosis.
BACKGROUND Since the use of parathyroid hormone as a treatment for osteoporosis is limited to two years or less, the question of whether antiresorptive therapy should follow parathyroid hormone therapy is important. We previously reported results after the first year of this randomized trial comparing the use of full-length parathyroid hormone (1-84) alone, alendronate alone, or both combined. ...
متن کاملDaily and cyclic parathyroid hormone in women receiving alendronate.
BACKGROUND We evaluated whether patients with osteoporosis treated with long-term alendronate have a response to parathyroid hormone treatment and whether short, three-month cycles of parathyroid hormone therapy could be as effective as daily administration. METHODS We randomly assigned 126 women with osteoporosis who had been taking alendronate for at least 1 year to continued alendronate pl...
متن کاملReview: parathyroid hormone increases lumbar spine bone mineral density and decreases vertebral fractures in osteoporosis.
M a i n r e s u l t s 20 RCTs (2361 patients) met the selection criteria. Types of osteoporosis included postmenopausal osteoporosis (10 RCTs), idiopathic male osteoporosis (2 RCTs), and glucocorticoid-induced osteoporosis (1 RCT). 18 RCTs evaluated human PTH(l-34) administered subcutaneously. Dosages of PTH varied markedly among RCTs. Treatment duration ranged from 6 weeks to 3 years. Comparis...
متن کاملUpdate on the efficacy, safety, and adherence to treatment of full length parathyroid hormone, PTH (1-84), in the treatment of postmenopausal osteoporosis
Full length (1-84) parathyroid hormone (PTH) was introduced in Europe as a treatment for postmenopausal osteoporosis in 2006. The efficacy of PTH (1-84) in the prevention of vertebral fractures is very high, and is similar to that of teriparatide. Its action in the prevention of femoral fractures has yet to be fully demonstrated, but the incidence of such fractures in trials was very low, and a...
متن کاملEvaluation of a fully automated serum assay for total N-terminal propeptide of type I collagen in postmenopausal osteoporosis.
BACKGROUND Biochemical markers of bone turnover can provide prognostic information about the risk of fracture and may be useful for monitoring efficacy of antiresorptive and anabolic therapy in osteoporosis. We evaluated the performance of a fully automated assay for serum total N-terminal propeptide of type I collagen (P1NP), a marker of bone formation. METHODS Serum P1NP was measured on the...
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ورودعنوان ژورنال:
- ACP journal club
دوره 144 1 شماره
صفحات -
تاریخ انتشار 2006